Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism.

Pharmacogenetics and genomics - 1 Jan 2018

Tanner Julie-Anne, Zhu Andy Z, Claw Katrina G, Prasad Bhagwat, Korchina Viktoriya, Hu Jianhong, Doddapaneni HarshaVardhan, Muzny Donna M, Schuetz Erin G, Lerman Caryn, Thummel Kenneth E, Scherer Steven E, Tyndale Rachel F

Abstract excerpt

OBJECTIVES: Smoking patterns and cessation rates vary widely across smokers and can be influenced by variation in rates of nicotine metabolism [i.e. cytochrome P450 2A6 (CYP2A6), enzyme activity]. There is high heritability of CYP2A6-mediated nicotine metabolism (60-80%) owing to known and unidentified genetic variation in the CYP2A6 gene. We aimed to identify and characterize additional genetic variants at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 CYP2A6
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Linkage Disequilibrium

Share to Nicotine

Share to Tissue Banks

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 29232328
DOI: 10.1097/FPC.0000000000000317
PMCID: PMC5729933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism.PMID 29232328Read ↗

Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes.Semantic proximity Read ↗

Genotyping, characterization, and imputation of known and novel CYP2A6 structural variants using SNP array data.Semantic proximity Read ↗

Predicting nicotine metabolism across ancestries using genotypes.Semantic proximity Read ↗

Predicting Nicotine Metabolism Across Ancestries Using GenotypesSemantic proximity Read ↗

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.Semantic proximity Read ↗

Ethnic variation in CYP2A6*7, CYP2A6*8 and CYP2A6*10 as assessed with a novel haplotyping method.Semantic proximity Read ↗

Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors.Semantic proximity Read ↗

Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6.Semantic proximity Read ↗

Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activitySemantic proximity Read ↗

A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo.Semantic proximity Read ↗

PharmVar GeneFocus: CYP2A6.Semantic proximity Read ↗

Genetic variability in CYP2A6 and the pharmacokinetics of nicotine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.