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Article

Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6.

Human molecular genetics - 1 Jul 2012

Bloom A Joseph, Harari Oscar, Martinez Maribel, Madden Pamela A F, Martin Nicholas G, Montgomery Grant W, Rice John P, Murphy Sharon E, Bierut Laura J, Goate Alison

Abstract excerpt

This study demonstrates a novel approach to test associations between highly heterogeneous genetic loci and complex phenotypes. Previous investigations of the relationship between Cytochrome P450 2A6 (CYP2A6) genotype and smoking phenotypes made comparisons by dividing subjects into broad categories based on assumptions that simplify the range of function of different CYP2A6 alleles, their numerous possible...

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Share to Aryl Hydrocarbon Hydroxylases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22451501
DOI: 10.1093/hmg/dds114
PMCID: PMC3373237

Genes

CPD

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