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Article

PLZF regulates CCR6 and is critical for the acquisition and maintenance of the Th17 phenotype in human cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2015

Singh Satya P, Zhang Hongwei H, Tsang Hsinyi, Gardina Paul J, Myers Timothy G, Nagarajan Vijayaraj, Lee Chang Hoon, Farber Joshua M

Abstract excerpt

Th17 cells, which express the chemokine receptor CCR6, are implicated in many immune-mediated disorders, such as psoriasis and multiple sclerosis. We found that expression levels of CCR6 on human effector/memory CD4(+) T cells reflect a continuum of Th17 differentiation. By evaluating the transcr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kruppel-Like Transcription Factors

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Source

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Identifiers

PMID: 25833398
DOI: 10.4049/jimmunol.1401093
PMCID: PMC4412463

Genes

CCR6
ZBTB16
RORC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25833398-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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