Article
PLZF regulates CCR6 and is critical for the acquisition and maintenance of the Th17 phenotype in human cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2015
Singh Satya P, Zhang Hongwei H, Tsang Hsinyi, Gardina Paul J, Myers Timothy G, Nagarajan Vijayaraj, Lee Chang Hoon, Farber Joshua M
Abstract excerpt
Th17 cells, which express the chemokine receptor CCR6, are implicated in many immune-mediated disorders, such as psoriasis and multiple sclerosis. We found that expression levels of CCR6 on human effector/memory CD4(+) T cells reflect a continuum of Th17 differentiation. By evaluating the transcriptome in cells with increasing CCR6, we detected progressive upregulation of ZBTB16, which encodes the broad complex,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.