Article
ERAP1 Gene Expression Is Influenced by Nonsynonymous Polymorphisms Associated With Predisposition to Spondyloarthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2015
Costantino Félicie, Talpin Alice, Evnouchidou Irini, Kadi Amir, Leboime Ariane, Said-Nahal Roula, Bonilla Nelly, Letourneur Franck, Leturcq Tifenn, Ka Zeyna, van Endert Peter, Garchon Henri-Jean, Chiocchia Gilles, Breban Maxime
Abstract excerpt
OBJECTIVE: Several polymorphisms in ERAP1 are strongly associated with susceptibility to spondyloarthritis (SpA). The combination of rs17482078, rs10050860, and rs30187 results in the construction of 3 major haplotypes that are associated with SpA (the "protective" haplotype T/T/C, the "neutral" haplotype C/C/C, and the "susceptibility" haplotype C/C/T). The aim of the present study was to determine whether such...
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