Article
A neomorphic syntaxin mutation blocks volatile-anesthetic action in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 1999
van Swinderen B, Saifee O, Shebester L, Roberson R, Nonet M L, Crowder C M
Abstract excerpt
The molecular mechanisms underlying general anesthesia are unknown. For volatile general anesthetics (VAs), indirect evidence for both lipid and protein targets has been found. However, no in vivo data have implicated clearly any particular lipid or protein in the control of sensitivity to clinical concentrations of VAs. Genetics provides one approach toward identifying these mechanisms, but genes strongly...
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