Article
Optical reversal of halothane-induced immobility in C. elegans.
Current biology : CB - 20 Dec 2011
Singaram Vinod K, Somerlot Benjamin H, Falk Scott A, Falk Marni J, Sedensky Margaret M, Morgan Philip G
Abstract excerpt
Volatile anesthetics (VAs) cause profound neurological effects, including reversible loss of consciousness and immobility. Despite their widespread use, the mechanism of action of VAs remains one of the unsolved puzzles of neuroscience [1, 2]. Genetic studies in Caenorhabditis elegans [3, 4], Drosophila [3, 5], and mice [6-9] indicate that ion channels controlling the neuronal resting membrane potential (RMP)...
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