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Article

A gain-of-function mutation in adenylate cyclase confers isoflurane resistance in Caenorhabditis elegans.

Anesthesiology - 1 Dec 2011

Saifee Owais, Metz Laura B, Nonet Michael L, Crowder C Michael

Abstract excerpt

BACKGROUND: Volatile general anesthetics inhibit neurotransmitter release by a mechanism not fully understood. Genetic evidence in Caenorhabditis elegans has shown that a major mechanism of action of volatile anesthetics acting at clinical concentrations in this animal is presynaptic inhibition of neurotransmission. To define additional components of this presynaptic volatile anesthetic mechanism, C. elegans...

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Source

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Identifiers

PMID: 22024713
DOI: 10.1097/ALN.0b013e318239355d
PMCID: PMC3226976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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