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Article

Apolipoprotein ε4 is associated with lower brain volume in cognitively normal Chinese but not white older adults.

PloS one - 1 Jan 2015

Yokoyama Jennifer S, Lee Allen K L, Takada Leonel T, Busovaca Edgar, Bonham Luke W, Chao Steven Z, Tse Marian, He Jing, Schwarz Christopher G, Carmichael Owen T, Matthews Brandy R, Karydas Anna, Weiner Michael W, Coppola Giovanni, DeCarli Charles S, Miller Bruce L, Rosen Howard J

Abstract excerpt

Studying ethnically diverse groups is important for furthering our understanding of biological mechanisms of disease that may vary across human populations. The ε4 allele of apolipoprotein E (APOE ε4) is a well-established risk factor for Alzheimer's disease (AD), and may confer anatomic and functional effects years before clinical signs of cognitive decline are observed. The allele frequency of APOE ε4 varies...

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Identifiers

PMID: 25738563
DOI: 10.1371/journal.pone.0118338
PMCID: PMC4349764

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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