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Two Alzheimer’s disease risk genes increase entorhinal cortex volume in young adults

6 Oct 2014

Abstract excerpt

Alzheimer's disease (AD) risk genes alter brain structure and function decades before disease onset. Apolipoprotein E (APOE) is the strongest known genetic risk factor for AD, and a related gene, apolipoprotein J (APOJ), also affects disease risk. However, the extent to which these genes affect brain structure in young adults remains unclear. Here, we report that AD risk alleles of these two genes, APOE-ε4 and...

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PMID: 25339884
DOI: 10.3389/fnhum.2014.00779

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