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Article

Est1 and Cdc13 as comediators of telomerase access.

Science (New York, N.Y.) - 1 Oct 1999

Evans S K, Lundblad V

Abstract excerpt

Cdc13 and Est1 are single-strand telomeric DNA binding proteins that contribute to telomere replication in the yeast Saccharomyces cerevisiae. Here it is shown that fusion of Cdc13 to the telomerase-associated Est1 protein results in greatly elongated telomeres. Fusion proteins consisting of mutant versions of Cdc13 or Est1 confer similar telomere elongation, indicating that close physical proximity can bypass...

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Source

Identifiers

PMID: 10506558
DOI: 10.1126/science.286.5437.117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Est1 and Cdc13 as comediators of telomerase access.PMID 10506558Read ↗

The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro.Semantic proximity Read ↗

A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle.Semantic proximity Read ↗

Delivery of yeast telomerase to a DNA break depends on the recruitment functions of Cdc13 and Est1.Semantic proximity Read ↗

The mechanisms of K. lactis Cdc13 in telomere DNA-binding and telomerase regulation.Semantic proximity Read ↗

The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein.Semantic proximity Read ↗

Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment.Semantic proximity Read ↗

A second essential function of the Est1-binding arm of yeast telomerase RNA.Semantic proximity Read ↗

Est1p as a cell cycle-regulated activator of telomere-bound telomerase.Semantic proximity Read ↗

The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA.Semantic proximity Read ↗

Est1 protects telomeres and inhibits subtelomeric y'-element recombination.Semantic proximity Read ↗

A Human Homolog of Yeast Est1 Associates with Telomerase and Uncaps Chromosome Ends When OverexpressedSemantic proximity Read ↗

Linear chromosome maintenance in the absence of essential telomere-capping proteins.Semantic proximity Read ↗

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