Article

Monogenic and Polygenic Contributions to QTc Prolongation in the Population

2021-06-21

Abstract excerpt

<h4>Background</h4> Rare sequence variation in genes underlying the long QT syndrome (LQTS) and common polygenic variation influence QT interval duration. It is unclear how rare and common variation contribute to QT interval duration in the general population. <h4>Objectives</h4> Investigate monogenic and polygenic contributions to QT interval duration and the role of polygenic variation in modulating phenotypic e...

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Literature Corpus work: 53ba3263-5ec2-5522-a303-8925131be7a2
DOI: 10.1101/2021.06.18.21258578

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