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Article

Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progression.

Scientific reports - 6 Jun 2016

Hintermair Corinna, Voß Kirsten, Forné Ignasi, Heidemann Martin, Flatley Andrew, Kremmer Elisabeth, Imhof Axel, Eick Dirk

Abstract excerpt

Dynamic phosphorylation of Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 heptad-repeats in the C-terminal domain (CTD) of the large subunit coordinates progression of RNA polymerase (Pol) II through the transcription cycle. Here, we describe an M phase-specific form of Pol II phosphorylated at Thr4, but not at Tyr1, Ser2, Ser5, and Ser7 residues. Thr4 phosphorylated Pol II binds to centrosomes and midbody and interacts with...

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Identifiers

PMID: 27264542
DOI: 10.1038/srep27401
PMCID: PMC4893663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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