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Article

Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis.

PloS one - 1 Jan 2015

Bos Steffan D, Page Christian M, Andreassen Bettina K, Elboudwarej Emon, Gustavsen Marte W, Briggs Farren, Quach Hong, Leikfoss Ingvild S, Bjølgerud Anja, Berge Tone, Harbo Hanne F, Barcellos Lisa F

Abstract excerpt

OBJECTIVE: Determine whether MS-specific DNA methylation profiles can be identified in whole blood or purified immune cells from untreated MS patients. METHODS: Whole blood, CD4+ and CD8+ T cell DNA from 16 female, treatment naïve MS patients and 14 matched controls was profiled using the HumanMethylation450K BeadChip. Genotype data were used to assess genetic homogeneity of our sample and to exclude potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25734800
DOI: 10.1371/journal.pone.0117403
PMCID: PMC4348521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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