Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis.

doi:10.1038/nature08990

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis.

Nature - 29 Apr 2010

Baranzini Sergio E, Mudge Joann, van Velkinburgh Jennifer C, Khankhanian Pouya, Khrebtukova Irina, Miller Neil A, Zhang Lu, Farmer Andrew D, Bell Callum J, Kim Ryan W, May Gregory D, Woodward Jimmy E, Caillier Stacy J, McElroy Joseph P, Gomez Refujia, Pando Marcelo J, Clendenen Leonda E, Ganusova Elena E, Schilkey Faye D, Ramaraj Thiruvarangan, Khan Omar A, Huntley Jim J, Luo Shujun, Kwok Pui-Yan, Wu Thomas D, Schroth Gary P, Oksenberg Jorge R, Hauser Stephen L, Kingsmore Stephen F

Abstract excerpt

Monozygotic or 'identical' twins have been widely studied to dissect the relative contributions of genetics and environment in human diseases. In multiple sclerosis (MS), an autoimmune demyelinating disease and common cause of neurodegeneration and disability in young adults, disease discordance in monozygotic twins has been interpreted to indicate environmental importance in its pathogenesis. However, genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allelic Imbalance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Breast

Share to CD4-Positive T-Lymphocytes

Share to CpG Islands

Share to INDEL Mutation

Share to Lung

Share to Multiple Sclerosis

Share to Twins, Monozygotic

Source

Open in PubMed Open full text

Identifiers

PMID: 20428171
DOI: 10.1038/nature08990
PMCID: PMC2862593

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis.PMID 20428171Read ↗

DNA Methylation Signatures of a Large Cohort Monozygotic Twins Clinically Discordant for Multiple SclerosisSemantic proximity Read ↗

DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosisSemantic proximity Read ↗

Genome, epigenome and transcriptome analyses of a pair of monozygotic twins discordant for systemic lupus erythematosus.Semantic proximity Read ↗

Epigenetics of discordant monozygotic twins: implications for diseaseSemantic proximity Read ↗

Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis.Semantic proximity Read ↗

Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differencesSemantic proximity Read ↗

DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated GenesSemantic proximity Read ↗

Genome-Wide Analysis of DNA Methylation, Copy Number Variation, and Gene Expression in Monozygotic Twins Discordant for Primary Biliary CirrhosisSemantic proximity Read ↗

The epigenetic mechanism for discordance of autoimmunity in monozygotic twins.Semantic proximity Read ↗

Blood ties: chimerism can mask twin discordance in high-throughput sequencing.Semantic proximity Read ↗

Monozygotic twin pairs discordant for amyotrophic lateral sclerosis carry both common and unique epigenetic differences relevant to diseaseSemantic proximity Read ↗

Deep characterization of paired chromatin and transcriptomes in four immune cell types from multiple sclerosis patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.