Article
Determination of the genotype and phenotype of serum paraoxonase 1 (PON1) status in a group of agricultural and nonagricultural workers in the Coquimbo Region, Chile.
Journal of toxicology and environmental health. Part A - 1 Jan 2015
Zúñiga-Venegas L, Aquea G, Taborda M, Bernal G, Pancetti F
Abstract excerpt
Paraoxonase 1 (PON1) is a glycosylated enzyme that is found associated with high-density lipoproteins in blood. In addition to its endogenous antioxidant role, this enzyme is also involved in hydrolysis of organophosphate (OP) pesticides in plasma. PON1 activity shows great variability in the population as a result of a polymorphism in the coding sequence that is expressed as a Glu(Q)/Arg(R) substitution at...
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