Article
Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities.
Molecular psychiatry - 1 Jun 2015
Madison J M, Zhou F, Nigam A, Hussain A, Barker D D, Nehme R, van der Ven K, Hsu J, Wolf P, Fleishman M, O'Dushlaine C, Rose S, Chambert K, Lau F H, Ahfeldt T, Rueckert E H, Sheridan S D, Fass D M, Nemesh J, Mullen T E, Daheron L, McCarroll S, Sklar P, Perlis R H, Haggarty S J
Abstract excerpt
Bipolar disorder (BD) is a common neuropsychiatric disorder characterized by chronic recurrent episodes of depression and mania. Despite evidence for high heritability of BD, little is known about its underlying pathophysiology. To develop new tools for investigating the molecular and cellular basis of BD, we applied a family-based paradigm to derive and characterize a set of 12 induced pluripotent stem cell...
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