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Single-cell multiomics analysis reveals cell/tissue-specific associations in bipolar disorder

6 Aug 2024

Abstract excerpt

This study investigates the cellular origin and tissue heterogeneity in bipolar disorder (BD) by integrating multiomics data. Four distinct datasets were employed, including single-cell RNA sequencing (scRNA-seq) data (embryonic and fetal brain, n = 8, 1,266 cells), BD Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) data (adult brain, n = 210), BD bulk RNA-seq data (adult brain, n = 314),...

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PMID: 39107272
DOI: 10.1038/s41398-024-03044-1

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