Article
Family-based exome-sequencing approach identifies rare susceptibility variants for lithium-responsive bipolar disorder.
Genome - 1 Oct 2013
Cruceanu Cristiana, Ambalavanan Amirthagowri, Spiegelman Dan, Gauthier Julie, Lafrenière Ronald G, Dion Patrick A, Alda Martin, Turecki Gustavo, Rouleau Guy A
Abstract excerpt
Bipolar disorder (BD) is a psychiatric condition characterized by the occurrence of at least two episodes of clinically disturbed mood including mania and depression. A vast literature describing BD studies suggests that a strong genetic contribution likely underlies this condition; heritability is estimated to be as high as 80%. Many studies have identified BD susceptibility loci, but because of the genetic and...
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