Article
New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways.
Biological psychiatry - 15 Aug 2025
O'Connell Kevin S, Adolfsson Rolf, Andlauer Till F M, Bauer Michael, Baune Bernhaud, Biernacka Joanna M, Carpiniello Bernardo, Cichon Sven, Craddock Nick, Cuellar-Barboza Alfredo B, Dannlowski Udo, Degenhardt Franziska, Dikeos Dimitris, Ferentinos Panagiotis, Forstner Andreas J, Frye Mark A, Fullerton Janice M, Grigoroiu-Serbanescu Maria, Guzman-Parra José, Jones Lisa, Jonsson Lina, Kircher Tilo, Kogevinas Manolis, Landén Mikael, Lissowska Jolanta, Lochner Christine, Manchia Mirko, Mayoral Fermin, McElroy Susan L, McGregor Nathaniel W, Meyer-Lindenberg Andreas, Mitchell Philip B, Müller-Myhsok Bertram, Nöthen Markus M, Patrinos George P, Pawlak Joanna M, Reif Andreas, Rietschel Marcella, Schofield Peter R, Schulze Thomas G, Serretti Alessandro, Smoller Jordan W, Squassina Alessio, Stein Dan J, Streit Fabian, Świątkowska Beata, Tondo Leonardo, Vieta Eduard, Waldman Irwin D, Dale Anders M, Andreassen Ole A
Abstract excerpt
Bipolar disorder (BD) is a highly heritable mental disorder that affects millions of people worldwide. Our understanding of the genetic etiology and biological processes that underlie BD have greatly increased in recent years. Extensive progress has been made in identifying common variant signals for BD, and the polygenic score from the latest genome-wide association study (GWAS) may provide some clinical utility...
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