Article
Trans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo.
Scientific reports - 3 Mar 2015
He Xingxing, Liu Fang, Yan Jingjun, Zhang Yunan, Yan Junwei, Shang Haitao, Dou Qian, Zhao Qiu, Song Yuhu
Abstract excerpt
Reactivation of wild-type p53 (wt-p53) function is an attractive therapeutic approach to p53-defective cancers. An ideal p53-based gene therapy should restore wt-p53 production and reduces mutant p53 transcripts simultaneously. In this study, we described an alternative strategy named as trans-splicing that repaired mutant p53 transcripts in hepatocellular carcinoma (HCC) cells. The plasmids which encoded a...
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