Article
Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2004
Shin Kyung-Sook, Sullenger Bruce A, Lee Seong-Wook
Abstract excerpt
A variety of mutations in the p53 tumor suppressor gene have been found in over half of human tumors. Thus, restoration of wild-type p53 activity by repair of mutant RNA has been previously suggested as an approach to cancer treatment. To explore the potential utility of RNA repair for cancer therapy, we developed a group I intron-based ribozyme that can replace mutant p53 RNA with a wild-type RNA sequence...
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