Article
A novel suicide gene therapy system for p53-mutated cells using a wild-type p53-specific promoter and Cre/loxP switch.
Surgery today - 1 Jan 2002
Mizumoto Masaki, Arii Shigeki, Furutani Masaharu, Mori Akira, Imamura Masayuki
Abstract excerpt
Approximately half of all malignant tumors have a mutation or deficiency in the p53 tumor suppressor gene. The present study was designed to develop a p53-mutated cancer cell-specific suicide gene therapy system using p53 as a transcriptional activating factor. We introduced the promoter containing the wild-type p53-specific binding sequence (p53SP) and the Cre/loxP exchange system to induce specific expression...
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