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Article

Proteasomal control of cytokinin synthesis protects Mycobacterium tuberculosis against nitric oxide.

Molecular cell - 19 Mar 2015

Samanovic Marie I, Tu Shengjiang, Novák Ondřej, Iyer Lakshminarayan M, McAllister Fiona E, Aravind L, Gygi Steven P, Hubbard Stevan R, Strnad Miroslav, Darwin K Heran

Abstract excerpt

One of several roles of the Mycobacterium tuberculosis proteasome is to defend against host-produced nitric oxide (NO), a free radical that can damage numerous biological macromolecules. Mutations that inactivate proteasomal degradation in Mycobacterium tuberculosis result in bacteria that are hypersensitive to NO and attenuated for growth in vivo, but it was not known why. To elucidate the link between...

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Identifiers

PMID: 25728768
DOI: 10.1016/j.molcel.2015.01.024
PMCID: PMC4369403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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