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Article

The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide.

Science (New York, N.Y.) - 12 Dec 2003

Darwin K Heran, Ehrt Sabine, Gutierrez-Ramos José-Carlos, Weich Nadine, Nathan Carl F

Abstract excerpt

The production of nitric oxide and other reactive nitrogen intermediates (RNI) by macrophages helps to control infection by Mycobacterium tuberculosis (Mtb). However, the protection is imperfect and infection persists. To identify genes that Mtb requires to resist RNI, we screened 10,100 Mtb transposon mutants for hypersusceptibility to acidified nitrite. We found 12 mutants with insertions in seven genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14671303
DOI: 10.1126/science.1091176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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