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Article

Urease activity represents an alternative pathway for Mycobacterium tuberculosis nitrogen metabolism.

Infection and immunity - 1 Aug 2012

Lin Wenwei, Mathys Vanessa, Ang Emily Lei Yin, Koh Vanessa Hui Qi, Martínez Gómez Julia María, Ang Michelle Lay Teng, Zainul Rahim Siti Zarina, Tan Mai Ping, Pethe Kevin, Alonso Sylvie

Abstract excerpt

Urease represents a critical virulence factor for some bacterial species through its alkalizing effect, which helps neutralize the acidic microenvironment of the pathogen. In addition, urease serves as a nitrogen source provider for bacterial growth. Pathogenic mycobacteria express a functional urease, but its role during infection has yet to be characterized. In this study, we constructed a urease-deficient...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22645285
DOI: 10.1128/IAI.06195-11
PMCID: PMC3434571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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