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Article

Identification of substrates of the Mycobacterium tuberculosis proteasome.

The EMBO journal - 15 Nov 2006

Pearce Michael J, Arora Pooja, Festa Richard A, Butler-Wu Susan M, Gokhale Rajesh S, Darwin K Heran

Abstract excerpt

The putative proteasome-associated proteins Mpa (Mycobaterium proteasomal ATPase) and PafA (proteasome accessory factor A) of the human pathogen Mycobacterium tuberculosis (Mtb) are essential for virulence and resistance to nitric oxide. However, a direct link between the proteasome protease and Mpa or PafA has never been demonstrated. Furthermore, protein degradation by bacterial proteasomes in vitro has not...

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Identifiers

PMID: 17082771
DOI: 10.1038/sj.emboj.7601405
PMCID: PMC1636610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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