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Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host.

mBio - 3 Mar 2020

Healy Claire, Gouzy Alexandre, Ehrt Sabine

Abstract excerpt

Synthesis and cleavage of the cell wall polymer peptidoglycan (PG) are carefully orchestrated processes and are essential for the growth and survival of bacteria. Yet, the function and importance of many enzymes that act on PG in Mycobacterium tuberculosis remain to be elucidated. We demonstrate that the activity of the N-acetylmuramyl-l-alanine amidase Ami1 is dispensable for cell division in M. tuberculosisin...

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Identifiers

PMID: 32127458
DOI: 10.1128/mBio.03315-19
PMCID: PMC7064781

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