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Article

ATOH8 binds SMAD3 to induce cellular senescence and prevent Ras-driven malignant transformation

10 Jan 2023

Abstract excerpt

The process of oncogene-induced senescence (OIS) and the conversion between OIS and malignant transformation during carcinogenesis is poorly understood. Here, we show that following overactivation of oncogene Ras in lung epithelial cells, high-level transforming growth factor β1 (TGF-β1)–activated SMAD3, but not SMAD2 or SMAD4, plays a determinant role in inducing cellular senescence independent of the...

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PMID: 36626550
DOI: 10.1073/pnas.2208927120

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