Elimination of p19ARF-expressing cells enhances pulmonary function in mice

Abstract excerpt

Senescent cells accumulate in many tissues as animals age and are considered to underlie several aging-associated pathologies. The tumor suppressors p19 ARF and p16 INK4a , both of which are encoded in the CDKN2A locus, play critical roles in inducing and maintaining permanent cell cycle arrest during cellular senescence. Although the elimination of p16 INK4a -expressing cells extends the life span of the mouse,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related Molecular Pathways
• Share to Epigenetics and DNA Methylation
• Share to Telomeres, Telomerase, and Senescence