Article

p16-3MR: a novel model to study cellular senescence in cigarette smoke-induced lung injuries during aging

2021-02-23

Abstract excerpt

<h4>ABSTRACT</h4> Cellular senescence and lung aging are associated with the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). COPD progresses with aging, and chronic smoking is the key susceptibility factor in lung pathological changes concurrent with biological aging. However, these processes involving cigarette smoke (CS)-mediated lung cellular senescence are difficult to distinguish. One of the im...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 270ff496-0f09-5f3b-bc7d-49778d1f53d5
DOI: 10.1101/2021.02.23.432412

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

p16-3MR: a novel model to study cellular senescence in cigarette smoke-induced lung injuries during agingDOI 10.1101/2021.02.23.432412Read

p16-3MR: a novel model to study cellular senescence in cigarette smoke-induced lung injuries during agingSemantic proximity Read

Cellular Senescence: Mechanisms, Morphology, and Mouse ModelsSemantic proximity Read

Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in miceSemantic proximity Read

Cellular Senescence in the Lung: The Central Role of Senescent Epithelial CellsSemantic proximity Read

Lung cellular senescence is independent of aging in a mouse model of COPD/emphysemaSemantic proximity Read

Cellular Senescence in Lung FibrosisSemantic proximity Read

Genetic Ablation of p16INK4a Does Not Protect against Cellular Senescence in Mouse Models of Chronic Obstructive Pulmonary Disease/EmphysemaSemantic proximity Read

Ablation of <i>Arf</i> -expressing cells ameliorates cigarette smoke-induced lung dysfunction in miceSemantic proximity Read

Cellular Senescence: The Trojan Horse in Chronic Lung DiseasesSemantic proximity Read

Senescence-associated secretory phenotype and its possible role in chronic obstructive pulmonary disease.Semantic proximity Read

Cellular senescence in lung cancer: Molecular mechanisms and therapeutic interventionsSemantic proximity Read

Cellular senescence in chronic obstructive pulmonary disease: Molecular mechanisms and therapeutic interventionsSemantic proximity Read