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Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema

7 Jun 2018

Abstract excerpt

Cigarette smoke (CS) induces lung cellular senescence that plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). How aging influences cellular senescence and other molecular hallmarks, and increases the risk of CS-induced damage remains unknown. We hypothesized that aging-associated changes in lungs worsen the COPD/emphysema by CS exposure. Younger and older groups of...

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PMID: 29899396
DOI: 10.1038/s41598-018-27209-3

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