Article
Heterotypic paracrine signaling drives fibroblast senescence and tumor progression of large cell carcinoma of the lung.
Oncotarget - 13 Dec 2016
Lugo Roberto, Gabasa Marta, Andriani Francesca, Puig Marta, Facchinetti Federica, Ramírez Josep, Gómez-Caro Abel, Pastorino Ugo, Fuster Gemma, Almendros Isaac, Gascón Pere, Davalos Albert, Reguart Noemí, Roz Luca, Alcaraz Jordi
Abstract excerpt
Senescence in cancer cells acts as a tumor suppressor, whereas in fibroblasts enhances tumor growth. Senescence has been reported in tumor associated fibroblasts (TAFs) from a growing list of cancer subtypes. However, the presence of senescent TAFs in lung cancer remains undefined. We examined senescence in TAFs from primary lung cancer and paired control fibroblasts from unaffected tissue in three major...
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