Article
Second-generation PLINK: rising to the challenge of larger and richer datasets.
GigaScience - 1 Jan 2015
Chang Christopher C, Chow Carson C, Tellier Laurent Cam, Vattikuti Shashaank, Purcell Shaun M, Lee James J
Abstract excerpt
BACKGROUND: PLINK 1 is a widely used open-source C/C++ toolset for genome-wide association studies (GWAS) and research in population genetics. However, the steady accumulation of data from imputation and whole-genome sequencing studies has exposed a strong need for faster and scalable implementations of key functions, such as logistic regression, linkage disequilibrium estimation, and genomic distance evaluation....
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