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Article

Evaluation of an approximation method for assessment of overall significance of multiple-dependent tests in a genomewide association study.

Genetic epidemiology - 1 Dec 2011

Moskvina Valentina, O'Dushlaine Colm, Purcell Shaun, Craddock Nick, Holmans Peter, O'Donovan Michael C

Abstract excerpt

We describe implementation of a set-based method to assess the significance of findings from genomewide association study data. Our method, implemented in PLINK, is based on theoretical approximation of Fisher's statistics such that the combination of P-vales at a gene or across a pathway is carried out in a manner that accounts for the correlation structure, or linkage disequilibrium, between single nucleotide...

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Identifiers

PMID: 22006681
DOI: 10.1002/gepi.20636
PMCID: PMC3268180

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