Article
Shape-IT: new rapid and accurate algorithm for haplotype inference.
BMC bioinformatics - 16 Dec 2008
Delaneau Olivier, Coulonges Cédric, Zagury Jean-François
Abstract excerpt
BACKGROUND: We have developed a new computational algorithm, Shape-IT, to infer haplotypes under the genetic model of coalescence with recombination developed by Stephens et al in Phase v2.1. It runs much faster than Phase v2.1 while exhibiting the same accuracy. The major algorithmic improvements rely on the use of binary trees to represent the sets of candidate haplotypes for each individual. These binary tree...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.