Article
Efficient genomewide selection of PCA-correlated tSNPs for genotype imputation.
Annals of human genetics - 1 Nov 2011
Javed Asif, Drineas Petros, Mahoney Michael W, Paschou Peristera
Abstract excerpt
The linkage disequilibrium structure of the human genome allows identification of small sets of single nucleotide polymorphisms (SNPs) (tSNPs) that efficiently represent dense sets of markers. This structure can be translated into linear algebraic terms as evidenced by the well documented princip...
Topics
- Algorithms
- Black People
- Genome, Human
- Genome-Wide Association Study
- Genotype
- HapMap Project
- Humans
- Polymorphism, Single Nucleotide
- Principal Component Analysis