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Article

Unraveling the mechanistic features of RNA polymerase II termination by the 5'-3' exoribonuclease Rat1.

Nucleic acids research - 11 Mar 2015

Park Jieun, Kang Myungjin, Kim Minkyu

Abstract excerpt

Within a complex with Rai1, the 5'-3' exoribonuclease Rat1 promotes termination of RNA polymerase II (RNAPII) on protein-coding genes, but its underlying molecular mechanism is still poorly understood. Using in vitro transcription termination assays, we have found that RNAPII is prone to more effective termination by Rat1/Rai1 when its catalytic site is disrupted due to NTP misincorporation, implying that paused...

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Identifiers

PMID: 25722373
DOI: 10.1093/nar/gkv133
PMCID: PMC4357727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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