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Article

Codon 141 polymorphisms of the ovine prion protein gene affect the phenotype of classical scrapie transmitted from goats to sheep.

BMC veterinary research - 4 May 2017

Konold Timm, Phelan Laura J, Donnachie Ben R, Chaplin Melanie J, Cawthraw Saira, González Lorenzo

Abstract excerpt

BACKGROUND: A study to investigate transmission of classical scrapie via goat milk was carried out in sheep: firstly, lambs were challenged orally with goat scrapie brain homogenate to confirm transmission of scrapie from goats to sheep. In the second study phase, milk from scrapie-infected goats was fed to lambs. Lambs were selected according to their prion protein gene (PRNP) genotype, which was either VRQ/VRQ...

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Source

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Identifiers

PMID: 28472956
DOI: 10.1186/s12917-017-1036-1
PMCID: PMC5418773

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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