Article
Influence of breed and genotype on the onset and distribution of infectivity and disease-associated prion protein in sheep following oral infection with the bovine spongiform encephalopathy agent.
Journal of comparative pathology - 1 Jan 2015
McGovern G, Martin S, Jeffrey M, Bellworthy S J, Spiropoulos J, Green R, Lockey R, Vickery C M, Thurston L, Dexter G, Hawkins S A C, González L
Abstract excerpt
The onset and distribution of infectivity and disease-specific prion protein (PrP(d)) accumulation was studied in Romney and Suffolk sheep of the ARQ/ARQ, ARQ/ARR and ARR/ARR prion protein gene (Prnp) genotypes (where A stands for alanine, R for arginine and Q for glutamine at codons 136, 154 and 171 of PrP), following experimental oral infection with cattle-derived bovine spongiform encephalopathy (BSE) agent....
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