Article
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia.
Atherosclerosis - 1 Apr 2009
van der Net Jeroen B, Versmissen Jorie, Oosterveer Daniëlla M, Defesche Joep C, Yazdanpanah Mojgan, Aouizerat Bradley E, Steyerberg Ewout W, Malloy Mary J, Pullinger Clive R, Kane John P, Kastelein John J P, Sijbrands Eric J G
Abstract excerpt
OBJECTIVES: To investigate the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene as a potential modifier gene for coronary heart disease (CHD) in patients with familial hypercholesterolemia (FH). BACKGROUND: The ALOX5AP gene is required for the synthesis of leukotrienes, a protein family involved in inflammatory responses. Recently, genetic variation in this gene was shown to be associated with...
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