Article
The association between the gene encoding 5-lipoxygenase activating protein and abdominal aortic aneurysms.
Atherosclerosis - 1 Feb 2012
Bisoendial Radjesh J, Tanck Michael W, Golledge Jonathan, Broekhuizen Lysette N, Legemate Dink A, Stroes Erik S G, Norman Paul E
Abstract excerpt
BACKGROUND: Genetic variation in the gene ALOX5AP, encoding arachidonate 5-lipoxygenase-activating protein, have been suggested to increase risk for myocardial infarction and stroke. Leukotrienes (LTs) that derive from the 5-lipoxygenase (5-LO) cascade have been implicated in the pathogenesis of abdominal aortic aneurysm (AAA). METHODS AND RESULTS: The association of the ALOX5AP haplotypes with AAA was assessed...
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