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Article

Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.

Human genetics - 1 Mar 2009

Crosslin David R, Shah Svati H, Nelson Sarah C, Haynes Carol S, Connelly Jessica J, Gadson Shera, Goldschmidt-Clermont Pascal J, Vance Jeffery M, Rose Jason, Granger Chris B, Seo David, Gregory Simon G, Kraus William E, Hauser Elizabeth R

Abstract excerpt

Leukotrienes are arachidonic acid derivatives long known for their inflammatory properties and their involvement with a number of human diseases, most particularly asthma. Recently, leukotriene-based inflammation has also been shown to play an important role in atherosclerosis: ALOX5AP and LTA4H, both genes in the leukotriene biosynthesis pathway, have individually been shown to be associated with various...

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Identifiers

PMID: 19130089
DOI: 10.1007/s00439-008-0619-0
PMCID: PMC2759090

Genes

ALOX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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