Article
Low-expression variant of fatty acid-binding protein 4 favors reduced manifestations of atherosclerotic disease and increased plaque stability.
Circulation. Cardiovascular genetics - 1 Oct 2014
Saksi Jani, Ijäs Petra, Mäyränpää Mikko I, Nuotio Krista, Isoviita Pia M, Tuimala Jarno, Lehtonen-Smeds Erno, Kaste Markku, Jula Antti, Sinisalo Juha, Nieminen Markku S, Lokki Marja-Liisa, Perola Markus, Havulinna Aki S, Salomaa Veikko, Kettunen Johannes, Jauhiainen Matti, Kovanen Petri T, Lindsberg Perttu J
Abstract excerpt
BACKGROUND: Fatty acid-binding protein 4 (FABP4 or aP2 in mice) has been identified as a key regulator of core aspects of cardiometabolic disorders, including lipotoxic endoplasmic reticulum stress in macrophages. A functional promoter polymorphism (rs77878271) of human FABP4 gene has been described resulting in reduced FABP4 transcription. METHODS AND RESULTS: We investigated the effects of this low-expression...
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