Article
Fitness trade-offs explain low levels of persister cells in the opportunistic pathogen Pseudomonas aeruginosa.
Molecular ecology - 1 Apr 2015
Stepanyan Kristine, Wenseleers Tom, Duéñez-Guzmán Edgar A, Muratori Frédéric, Van den Bergh Bram, Verstraeten Natalie, De Meester Luc, Verstrepen Kevin J, Fauvart Maarten, Michiels Jan
Abstract excerpt
Microbial populations often contain a fraction of slow-growing persister cells that withstand antibiotics and other stress factors. Current theoretical models predict that persistence levels should reflect a stable state in which the survival advantage of persisters under adverse conditions is balanced with the direct growth cost impaired under favourable growth conditions, caused by the nonreplication of...
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