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Article

Pharmacodynamics, population dynamics, and the evolution of persistence in Staphylococcus aureus.

PLoS genetics - 1 Jan 2013

Johnson Paul J T, Levin Bruce R

Abstract excerpt

When growing populations of bacteria are confronted with bactericidal antibiotics, the vast majority of cells are killed, but subpopulations of genetically susceptible but phenotypically resistant bacteria survive. In accord with the prevailing view, these "persisters" are non- or slowly dividing cells randomly generated from the dominant population. Antibiotics enrich populations for pre-existing persisters but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23300474
DOI: 10.1371/journal.pgen.1003123
PMCID: PMC3536638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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