Article
Behavioral evidence for photophobia and stress-related ipsilateral head pain in transgenic Cacna1a mutant mice.
Pain - 1 Aug 2013
Chanda Mona Lisa, Tuttle Alexander H, Baran Inna, Atlin Cori, Guindi Daniella, Hathaway Georgia, Israelian Nyrie, Levenstadt Jeremy, Low Daniel, Macrae Lynn, O'Shea Louise, Silver Alex, Zendegui Elaina, Mariette Lenselink A, Spijker Sabine, Ferrari Michel D, van den Maagdenberg Arn M J M, Mogil Jeffrey S
Abstract excerpt
Migraine is a highly prevalent, disabling and complex episodic brain disorder whose pathogenesis is poorly understood, due in part to the lack of valid animal models. Here we report behavioral evidence of hallmark migraine features, photophobia and unilateral head pain, in transgenic knock-in mice bearing human familial hemiplegic migraine, type 1 (FHM-1) gain-of-function missense mutations (R192Q or S218L) in...
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