Article
Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice.
Hearing research - 1 Jan 2015
Inchauspe Carlota González, Pilati Nadia, Di Guilmi Mariano N, Urbano Francisco J, Ferrari Michel D, van den Maagdenberg Arn M J M, Forsythe Ian D, Uchitel Osvaldo D
Abstract excerpt
CaV2.1 Ca(2+) channels play a key role in triggering neurotransmitter release and mediating synaptic transmission. Familial hemiplegic migraine type-1 (FHM-1) is caused by missense mutations in the CACNA1A gene that encodes the α1A pore-forming subunit of CaV2.1 Ca(2+) channels. We used knock-in (KI) transgenic mice harbouring the pathogenic FHM-1 mutation R192Q to study inhibitory and excitatory...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.