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Article

Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 May 2014

Di Guilmi Mariano N, Wang Tiantian, Inchauspe Carlota Gonzalez, Forsythe Ian D, Ferrari Michel D, van den Maagdenberg Arn M J M, Borst J Gerard G, Uchitel Osvaldo D

Abstract excerpt

Specific missense mutations in the CACNA1A gene, which encodes a subunit of voltage-gated CaV2.1 channels, are associated with familial hemiplegic migraine type 1 (FHM1), a rare monogenic subtype of common migraine with aura. We used transgenic knock-in (KI) mice harboring the human pathogenic FH...

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Identifiers

PMID: 24849341
DOI: 10.1523/JNEUROSCI.2526-13.2014
PMCID: PMC4028489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-24849341-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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