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Article

Effects of lipid A acyltransferases on the pathogenesis of F. novicida.

Microbial pathogenesis - 1 Aug 2017

Yun Jian, Wang Xiaoyuan, Zhang Liang, Li Yanyan

Abstract excerpt

Francisella novicida is a gram-negative pathogen commonly used to study infections by the potential bioterrorism agent, Francisella tularensis. The Francisella lipid A structure has been well characterized and showed to affect the pathogenesis of F. novicida. Previous work characterized two lipid A acyltransferases, LpxD1 and LpxD2, and constructed the lpxD1-null and lpxD2-null mutants. Mutational analysis showed...

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Source

Identifiers

PMID: 28478203
DOI: 10.1016/j.micpath.2017.04.040

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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