Article
A genetic variation in microRNA target site of KRT81 gene is associated with survival in early-stage non-small-cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jun 2015
Lee S Y, Choi J E, Jeon H S, Hong M J, Choi Y Y, Kang H G, Yoo S S, Lee E B, Jeong J Y, Lee W K, Lee J, Cha S I, Kim C H, Kim Y T, Jheon S, Son J W, Park J Y
Abstract excerpt
BACKGROUND: MicroRNAs (miRNAs) have a key role in carcinogenesis through negative regulation of their target genes. Therefore, genetic variations in miRNAs or their target sites may affect miRNA-mRNA interactions, thereby result in altered expression of target genes. This study was conducted to investigate the associations between single-nucleotide polymorphisms (SNP) located in the miRNA target sites...
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